Five concentric rings with colorful DNA data in each ring, and an orange web design in the center.

Limitless possibilities revealed

Nested Therapeutics aims to advance precision oncology medicine by finding new driver mutations hiding in plain sight to reach a broader group of patients.

OUR APPROACH

It’s time to see through the
limits of precision medicine.

Precision medicine approaches are making steady progress in reaching more patients, but the fundamental problem of identifying driver alterations hiding in plain sight and uncovering novel targeting mechanisms to tap into a vast array of targets remains a significant bottleneck. Our purpose-built, insightful drug discovery platform enables us to find new, overlooked areas of opportunity in the form of high potential targets and design therapeutics for a perfect fit.

  • < 1% of the close to 10,000 recurrent cancer-associated mutations in the human genome have FDA approved medicines.
  • < 1 out of 7 advanced, metastatic cancer patients are eligible for existing precision medicines.

Building the platform to reveal
possibilities around every corner.

Our science-driven approach and collective drug discovery expertise guides our overarching drug design strategy. We innovate by leveraging mastery in genomics, computational biophysics, machine learning and chemical biology to look closer at molecular mechanisms selected in tumor evolution to ensure nothing is missed – whether mutations that create novel binding pockets are located at the interface of a broader protein complex, or if they are driving changes in protein conformation – we aim to find them.

OUR PLATFORM HAS THREE CRITICAL COMPONENTS:
MAP
mutational clusters onto the structural proteome
IDENTIFY
druggable pockets and cancer-driving mechanisms
DESIGN
novel drugs optimized for the druggable pocket
OUR PIPELINE

Our approach allows us to build a compelling pipeline leveraging novel binding pockets we’ve identified.

Nested’s lead program is NEST-1, a non-degrading, molecular glue that targets multiple critical components in the RAS/MAPK pathway. This differentiated therapeutic mechanism builds on Nested’s structural insights and has demonstrated superiority relative to single agent and vertical combinations in RAS/MAPK-driven models.

Nested is leveraging past success in targeting mutation-defined cryptic pockets to develop NEST-2 and NEST-3, allosteric molecules targeting a transcriptional regulator frequently mutated in cancer. Selective target binding has been demonstrated, and lead chemical series are advancing to in vivo proof-of-concept.

Program Target Discovery Preclinical IND-enabling P1/2Phase 1/2
Nest-1
Target: RAS/MAPK Pathway
Nest-2
Target: Mutated Transcription
Factor: Mutant #1
Nest-3
Target: Mutated Transcription
Factor: Mutant #2
Nest-4
Target: Undisclosed
New Targets
Target: Various
Building the Engine to Deliver 1 IND per Year Building the Engine to Deliver 1 IND per Year
OUR TEAM

We’re bringing a more insightful approach to precision oncology.

Our team includes pioneers of precision medicine who are now taking precision oncology to new heights. Comprised of the highest caliber of academic thought-leaders as founders and advisors, our team has collectively discovered and advanced 35 molecules to the clinic and developed 10 precision oncology medicines now on the market.

Team
Board of directors
Advisors
Investors
Black and white image of Darrin Miles , a man in a black T-shirt and glasses, smiling into the camera.

Darrin Miles

Chief Executive Officer

Klaus Hoeflich, Ph.D.

Chief Scientific Officer and Co-founder

Black and white image of Yongxin Han, a man with short, dark hair and glasses in a button-up, looking into the camera.

Yongxin Han, Ph.D.

Executive Vice President, Head of Drug Discovery

Patrick Athridge

Associate, Lab Operations

David Belanger

Director, Medicinal Chemistry

Steven Cohen

Scientist, Protein Sciences

Mark Fitzgerald

Director, Medicinal Chemistry

Beth Gunning

Senior Director, Controller

Jennifer Gyarfas

Associate Director, People Operations

Margit Hagel

Senior Director, Biology

Kamran Haider

Principal Scientist, Machine Learning Engineering

Michael Hale

Executive Director, Medicinal Chemistry

Anastasiya Hall

Administrative Business Associate

Matthew Hurley

Scientist, Computational Chemistry

Shashidhar Jatiani

Principal Scientist, Biology

Ahmad Al Kawam

Principal Scientist, Computational Biology and Bioinformatics

Matthew Koehler

Scientist, Proteomics

Siobhan McCarthy

Senior Research Associate, Biology

Weipeng Mu

Scientist, Biology

Monika Musial-Siwek

Director, Protein Sciences

Aysegul Ozen

Director, Computational Chemistry and Biophysics

Bradley Quade

Scientist, Structural Biology

Renata Reis

Scientist, Biochemistry

Maria Stella Ritorto

Director, Proteomics

Meagan Ryan

Scientist, Biology

Natasha Schenk

Scientist, Biology

Dietrich Steinhuebel

Executive Director, CMC

Matthew Strickland

Associate Scientist, Biology

Brooke Swalm

Principal Scientist, Biochemistry

Haiming Xu

Senior Scientist, Biology

Ruojing Yang

Director, Biology

Chaoyang Ye

Vice President, Data Science

Rhamy Zeid

Senior Director, Biology

Jianbo Zhao

Senior Scientist, Computational Chemistry

Julia Zhu

Director, Research Operations

Marshall Zingg

Associate Scientist, Biology

Black and white image of Darrin Miles , a man in a black T-shirt and glasses, smiling into the camera.

Darrin Miles

Director, Nested Therapeutics

Arvin Dar, Ph.D.

Observer, Nested Therapeutics

Jerel Davis, Ph.D.

Director, Versant Ventures

Josh Richardson, M.D.

Director, Goldman Sachs

Carlo Rizzuto, Ph.D.

Director, Versant Ventures

Adriana Tajonar, Ph.D.

Observer, Goldman Sachs

Ryan Corcoran M.D., Ph.D.

Scientific Advisor

Arvin Dar

Scientific Co-Founder

Cigall Kadoch, Ph.D.

Scientific Advisor

Tarun Kapoor

Scientific Advisor

Angela Koehler, Ph.D.

Scientific Advisor

Kevan Shokat, Ph.D.

Scientific Co-Founder

Darrin Miles

Black and white image of Darrin Miles , a man in a black T-shirt and glasses, smiling into the camera.

Darrin Miles is the Chief Executive Officer of Nested Therapeutics. From his more than twenty years in the healthcare industry, Darrin brings invaluable experience in leading biotech program strategy and development and successfully overseeing novel cancer therapies through approval and commercial success. Prior to joining Nested, Darrin was the Chief Commercial Officer of Agios Pharmaceuticals, where he led the oncology and rare disease commercialization strategy and functions. While at Agios, he led the precision oncology program management function through the development and approval of IDHIFA® and TIBSOVO®, for the treatment of mutant IDH acute myeloid leukemia. His leadership at Agios was instrumental in developing company culture and expanding program leadership and commercial capabilities. Before Agios, he spent fourteen years at Genentech, taking on increasing responsibilities in global program leadership, marketing, sales management and market access to support a variety of brands including Rituxan®, Herceptin®, Tarceva® and Lucentis®. Darrin earned his B.S. in Applied Economics from Cornell University.

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Klaus Hoeflich, Ph.D.

Dr. Klaus Hoeflich is Chief Scientific Officer and Co-Founder of Nested Therapeutics. He brings twenty years of experience in R&D of small molecule drug discovery to the team, as well as a passion for precision medicine. As a member of the founding team, he was drawn to Nested’s strong commitment to pursue novel mechanisms for high conviction targets in order to develop the next generation of precision oncology medicines. Previously, Klaus served as Senior Vice President of Biology at Blueprint Medicines, utilizing their expertise in protein kinases to advance precision therapies for genomic cancers, immuno-oncology, and rare diseases. Before his eight years at Blueprint Medicine, he spent eleven years at Genentech Inc., where his team helped advance several programs into clinical development, including the approval of Cotellic® for metastatic melanoma. Throughout his career, he has contributed to the development of four FDA-approved cancer medicines and has over seventy research publications. Klaus completed his B.S. in Biochemistry and Molecular Biology from Simon Fraser University and earned his Ph.D. in Medical Biophysics from the University of Toronto.

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Yongxin Han, Ph.D.

Black and white image of Yongxin Han, a man with short, dark hair and glasses in a button-up, looking into the camera.

Dr. Yongxin Han is the Executive Vice President and Head of Drug Discovery at Nested Therapeutics. In his career as a drug hunter, Yongxin led multiple teams in their discovery and advancement of twelve development candidates in oncology, immune-oncology, chronic HIV and HCV infections, pain and inflammation, metabolic disorders, hypertension, and glaucoma (PCCs). He also co-led and was a core member of several Early Development Teams that managed development activities up to clinical proof-of-concept. Before joining Nested Therapeutics, Yongxin spent more than 27 years at Merck Research Laboratories (MRL) in Montreal Canada, Shanghai China, and Boston USA. In his distinguished career at MRL, he served as a respected mentor, authored and co-authored over fifty-five publications in peer reviewed journals, and invented and co-invented more than seventy patents. Yongxin earned his Ph.D. in Organic Chemistry from the University of Alberta and completed his postdoctoral training from the University of British Columbia.

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Patrick Athridge

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David Belanger

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Steven Cohen

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Mark Fitzgerald

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Beth Gunning

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Jennifer Gyarfas

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Margit Hagel

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Kamran Haider

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Michael Hale

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Anastasiya Hall

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Matthew Hurley

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Shashidhar Jatiani

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Ahmad Al Kawam

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Matthew Koehler

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Siobhan McCarthy

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Weipeng Mu

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Monika Musial-Siwek

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Aysegul Ozen

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Bradley Quade

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Renata Reis

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Maria Stella Ritorto

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Meagan Ryan

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Natasha Schenk

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Dietrich Steinhuebel

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Matthew Strickland

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Brooke Swalm

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Haiming Xu

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Ruojing Yang

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Chaoyang Ye

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Rhamy Zeid

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Jianbo Zhao

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Julia Zhu

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Marshall Zingg

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Darrin Miles

Black and white image of Darrin Miles , a man in a black T-shirt and glasses, smiling into the camera.

Darrin Miles is the Chief Executive Officer of Nested Therapeutics. From his more than twenty years in the healthcare industry, Darrin brings invaluable experience in leading biotech program strategy and development and successfully overseeing novel cancer therapies through approval and commercial success. Prior to joining Nested, Darrin was the Chief Commercial Officer of Agios Pharmaceuticals, where he led the oncology and rare disease commercialization strategy and functions. While at Agios, he led the precision oncology program management function through the development and approval of IDHIFA® and TIBSOVO®, for the treatment of mutant IDH acute myeloid leukemia. His leadership at Agios was instrumental in developing company culture and expanding program leadership and commercial capabilities. Before Agios, he spent fourteen years at Genentech, taking on increasing responsibilities in global program leadership, marketing, sales management and market access to support a variety of brands including Rituxan®, Herceptin®, Tarceva® and Lucentis®. Darrin earned his B.S. in Applied Economics from Cornell University.

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Arvin Dar, Ph.D.

Dr. Arvin Dar is co-founder, consultant, and observing member of the Board of Directors at Nested Therapeutics. Additionally, he is a Professor in the Departments of Oncological Studies and Pharmacological Sciences at the Icahn School of Medicine at Mount Sinai, as well as Associate Director of the Mount Sinai Center for Therapeutic Discovery. Based on his background, Arvin brings a storied and unique blend of expertise in cancer biology, drug design and discovery, immunology, genetics, and small molecule chemistry to the Nested team. His lab takes an interdisciplinary approach to developing new classes of small molecule modulators for the Ras pathway in cancer biology, enabling the formulation of more innovative medicines. His groundbreaking research has earned him numerous awards and recognition, including the NIH Director’s New Innovator Award, Damon-Runyon Rachleff Innovation Award, the Pew Charitable Trusts Pew-Stewart Scholarship for Cancer Research, Pershing Square Sohn Cancer Research Alliance Award, Junior Faculty Award at Mount Sinai, Friedman Brain Institute Scholar Award, and the Mark Foundation for Cancer Research Aspire Award. Arvin earned his Ph.D. from the University of Toronto and completed his postdoctoral training at the University of California, San Francisco.

 

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Jerel Davis, Ph.D.

Dr. Jerel Davis has been a Director of Nested Therapeutics since Versant Ventures co-founded the company. As Managing Director at Versant, he has played a critical role in the firm’s company creation strategies and has been involved in more than 25 public and private biotech companies including BlueRock Tx, Crispr (CRSP), Repare (RPTX), Graphite (GRPH), Chinook (KDNY), Akero (AKRO), Rayze Bio, Ventus Tx, and Turnstone Bio. Prior to joining Versant, Jerel was an Associate Principal at McKinsey and Company where he advised healthcare corporations in pharmaceuticals, biotechnology, and medical device and worked in a number of healthcare markets globally. Jerel earned his doctorate from Stanford University, where he also completed post-doctoral research.

 

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Josh Richardson, M.D.

Josh Richardson serves on the board of Nested Therapeutics. He is currently a managing director in Growth Equity within Goldman Sachs Asset Management, focused on Life Sciences investing. Prior to joining the firm, Josh worked as a managing director at Longitude Capital, where he led investments in private and public biotechnology companies. Prior to that, he worked as a public equities analyst at HealthCor Management. Earlier in his career, Josh was a consultant with McKinsey & Company, where he worked in the Pharmaceutical and Private Equity practices. Josh earned his B.S. from the University of South Florida and his M.D. from the University of Virginia.

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Carlo Rizzuto, Ph.D.

Dr. Carlo Rizzuto has served as a Director at Nested Therapeutics since Versant Ventures co-founded the company. As a Managing Director at Versant, he has been instrumental in establishing Versant’s presence in the Northeast and in building and investing in a number of Versant’s portfolio companies including Pandion (acquired), Repare (RPTX), Century (IPSC), Graphite (GRPH), Jnana, 858, and Stablix. Carlo joined Versant from Novartis, where he led global product development teams in their advancement of new medicines. Before that, Carlo served as the Associate Principal for McKinsey & company, where he advised international clients in the pharmaceutical, payor and provider sectors. Carlo earned a Ph.D. in Virology from Harvard University.

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Adriana Tajonar, Ph.D.

Adriana is an observer on Nested’s Board of Directors. She currently serves as Vice President of Life Sciences Investing at Goldman Sachs, where she specializes in evaluating and facilitating investments in life sciences companies. Most recently, she served as Head of External Innovation at insitro, a biotechnology company applying machine learning to drug discovery. Previously,  she was a Principal at The Column Group, where she supported company-formation efforts in innovative therapeutics companies, building on her prior experience at QB3, a leading life science entrepreneurship institute at the University of California San Francisco. Adriana has also served on the boards of A2 Biotherapeutics, Accent Therapeutics and Carmot Therapeutics. She earned her Ph.D. in Stem Cell and Regenerative Biology from Harvard and her B.S. in Biology from MIT.

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Ryan Corcoran M.D., Ph.D.

Dr. Ryan Corcoran is a scientific advisor for Nested Therapeutics. He currently serves as the Director of the Gastrointestinal Cancer Center Program and the Scientific Director of the Termeer Center for Targeted Therapy at the Massachusetts General Hospital Cancer Center. He is an Associate Professor of Medicine at Harvard Medical School. Ryan directs a research laboratory focused on personalized cancer medicine: the development of therapeutic strategies that target the specific mutations driving individual patients’ tumors. His work focuses on understanding the molecular determinants of response or resistance to anti-cancer therapies. Ryan’s laboratory is also studying new ways to utilize liquid biopsy, and specifically analysis of circulating tumor DNA, in the clinic to optimize how we deliver cancer care to individual patients. Ryan is a member of the National Cancer Institute GI Steering Committee, and an elected member of the American Society for Clinical Investigation (ASCI). Ryan received his A.B. from Princeton University, and his M.D./Ph.D. from Stanford University. He completed his residency in Internal Medicine at the Massachusetts General Hospital and his fellowship in Medical Oncology at the Dana Faber Cancer Institute and the Massachusetts General Hospital Cancer Center. Ryan also co-founded Alterome Therapeutics.

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Arvin Dar

Dr. Arvin Dar is co-founder and observing member of the Board of Directors at Nested Therapeutics. Additionally, he is a Professor in the Departments of Oncological Studies and Pharmacological Sciences at the Icahn School of Medicine at Mount Sinai, as well as Associate Director of the Mount Sinai Center for Therapeutic Discovery. Based on his background, Arvin brings a storied and unique blend of expertise in cancer biology, drug design and discovery, immunology, genetics, and small molecule chemistry to the Nested team. His lab takes an interdisciplinary approach to developing new classes of small molecule modulators for the Ras pathway in cancer biology, enabling the formulation of more innovative medicines. His groundbreaking research has earned him numerous awards and recognition, including the NIH Director’s New Innovator Award, Damon-Runyon Rachleff Innovation Award, the Pew Charitable Trusts Pew-Stewart Scholarship for Cancer Research, Pershing Square Sohn Cancer Research Alliance Award, Junior Faculty Award at Mount Sinai, Friedman Brain Institute Scholar Award, and the Mark Foundation for Cancer Research Aspire Award. Arvin earned his Ph.D. from the University of Toronto and completed his postdoctoral training at the University of California, San Francisco.

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Cigall Kadoch, Ph.D.

Dr. Cigall Kadoch is a scientific advisor for Nested Therapeutics. She is an Associate Professor of Pediatric Oncology at the Dana-Farber Cancer Institute and Harvard Medical School, Institute Member and Epigenomics Program Co-Director at the Broad Institute of MIT and Harvard, and Investigator of the Howard Hughes Medical Institute. She is also the Scientific Founder of Foghorn Therapeutics (NASDAQ: FHTX). She established her independent laboratory in 2014, and was one of the youngest scientists ever appointed to the Harvard Medical School faculty at the age of 28. She has quickly become a leading expert in chromatin and gene regulation and is internationally recognized for her groundbreaking studies in these areas. Specifically, her laboratory studies the structure and function of nuclear protein complexes that govern DNA architecture and gene expression, known as chromatin remodeling complexes, perturbations in which cause a range of human cancers and neurodevelopmental disorders. Her work has catalyzed the development of several ongoing therapeutic development programs aimed to target a range of human diseases.

Dr. Kadoch has received numerous prestigious awards and research grants to support her academic laboratory at Harvard, including the NIH Director’s New Innovator Award, the American Association for the Advancement of Sciences (AAAS) Marin and Rose Wachtel Cancer Research Prize, and the American Association for Cancer Research (AACR) Outstanding Achievement in Basic Cancer Research Award, and the FASEB Excellence in Science Award. Additionally, over the past several years, she was named to the Forbes 30 Under 30 list, MIT Technology Review 35 Innovators Under 35, Popular Science Brilliant 10, Business Insider Top 30 Young leaders in Biopharma and Blavatnik National Awards. Cigall earned her Ph.D. in Cancer Biology at Stanford University.

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Tarun Kapoor

Dr. Tarun Kapoor is a scientific advisor for Nested Therapeutics. He is a faculty member in the David Rockefeller Graduate Program and the Tri-Institutional Ph.D. Program in Chemical Biology, where he also serves as Program Co-Director. He is head of the Selma and Lawrence Ruben Laboratory of Chemistry and Cell Biology at The Rockefeller University, which studies the molecular mechanisms required for accurate propagation of genetic material during cell division, with the goal of developing new therapies to treat cancer. Research in the lab has two areas of focus: discovering and developing new tools to probe protein function and using them to dissect dynamic cellular processes such as cytoskeleton organization and cell division. Tarun has earned many accolades for his work, including the Irving Sigal Young Investigator Award from The Protein Society, a Leukemia and Lymphoma Society Scholar Award, and recognition as a Pew Fellow in the Biomedical Sciences. Tarun received his Ph.D. in Chemistry from Harvard and completed his postdoctoral research at Harvard Medical School.

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Angela Koehler, Ph.D.

Dr. Angela Koehler is a scientific advisor for Nested Therapeutics. She is currently the Kathleen and Curtis Marble Professor in the Department of Biological Engineering at MIT and an Associate Director of the David H. Koch Institute for Integrative Cancer Research at MIT. She is also a member of the MIT Center for Cancer Precision Medicine and an Institute Member of the Broad Institute. The Koehler Lab aims to innovate in the earliest stages of drug discovery by building chemical tools or technologies to assist in the process of target validation and by expanding the repertoire of protein targets that are considered to be druggable. Angela also serves as Faculty Co-Director of the High-Throughput Sciences Facility at the Koch Institute, Faculty Co-Director of the MIT Biomedical Engineering Undergraduate Program, and a member of the Chemists in Cancer Research steering committee for the American Association for Cancer Research. Her research and contributions to her field have earned her many awards, including Novartis Lectureship in Chemistry, the Ono Foundation Pharma Breakthrough Science Award, and recognition as a Genome Technology Young Investigator. She has also founded several biotechnology companies, including Ligon Discovery, Kronos Bio, and 76Bio. Angela received her Ph.D. in Chemistry from Harvard University and her B.A. in Biochemistry and Molecular Biology from Reed College.

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Kevan Shokat, Ph.D.

Kevan Shokhat is a scientific co-founder of Nested Therapeutics. He is currently an Investigator of the Howard Hughes Medical Institute, Professor in the Department of Cellular and Molecular Pharmacology at UCSF and a Professor of Chemistry at UC Berkeley. He was inducted into the National Academy of Sciences (2010), the Institute of Medicine (2011), and the American Academy of Arts and Sciences (2011). His lab is most well-known for drugging the “undruggable” oncogene K-Ras (G12C) in 2013. K-Ras was the first human oncogene to be discovered in 1982 and remained undrugged until work from the Shokat lab at UCSF. In May of 2021, the drug sotorasib which binds to the same pocket on K-Ras (G12C) was approved for the treatment of lung cancer patients with this mutation. Recently his lab has applied covalent somatic cysteine targeting drugs to reactive the tumor suppressor p53 (Y220C) mutant. Kevan has been a co-founder of a number companies from their inception to public offering or acquisition: Intellikine (acquired by Takeda), Araxes (acquired by Janssen), eFFECTOR Pharmaceuticals (stock symbol: EFTR), Erasca (stock symbol: ERAS), Kura Oncology (stock symbol: KURA), and Revolution Medicines (stock symbol: RVMD). He is a co-founder of several currently private companies. Kevan earned his Ph.D. from the University of California, Berkeley.

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NEWS & MEDIA

Nested Therapeutics Launches With $125 Million Financing

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Breaking through
the limits of
precision medicine.

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